Hypusyne Formation on Eukaryotic Initiation Factor 5A 1997: Neurosignals Vol. 6, No. 3: Biochemistry and Function. Special Topic Issue

This collection of papers is devoted to the study of hypusine research. It explores the status of research on hypusine formation, a post-translational modification occurring in archaebacteria and eukaryotic cells, but not in eubacteria. Only one cellular protein, the eukaryotic initiator factor 5A (elF-5A), is known to contain the modified amino acid residue termed hypusine. Molecular genetics and pharmalogical studies indicate that this modification is essential for cell survival and proliferation. It has also been implicated as a cofactor in the action of HIV-1 viral protein Rev. Several laboratories have initiated efforts to exploit hypusine formation as a potential target site for cancer and AIDS chemotherapy. The major challenge is to define precisely the physiological role of elF-5A in cell growth regulation.

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